We enjoy sharing knowledge and insights from our research.
63] Cumulative burden of 144 conditions, critical care hospitalisation and premature mortality across 26 adult cancers (2023)
61] Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry (2023)
60] Comparing clinical trial population representativeness to real-world populations: an external validity analysis encompassing 43 895 trials and 5 685 738 individuals across 989 unique drugs and 286 conditions in England (2022)
59] Impact of anti-arrhythmic drugs and catheter ablation on the survival of patients with atrial fibrillation: a population study based on 199 433 new-onset atrial fibrillation patients in the UK (2022)
58] Multimorbidity patterns and risk of hospitalisation in children: A population cohort study of 3.6 million children in England, with illustrative examples from childhood cancer survivors (2022)
57] Depression, anxiety, substance misuse and self-harm in children and young people with rare chronic liver disease (2022)
56] Pan-cancer analyses of the associations between 109 pre-existing conditions and cancer treatment patterns across 19 adult cancers (2022)
55] There is no health without mental health: Challenges ignored and lessons learned (2022)
54] Pan-cancer prognostic genetic mutations and clinicopathological factors associated with survival outcomes: a systematic review (2022)
53] Autism and mental illness in children and young people require standardised approaches for assessment and treatment (2022)
52] Increased burden of cardiovascular disease in people with liver disease: unequal geographical variations, risk factors and excess years of life lost (2022)
51] Using national electronic health records for pandemic preparedness: validation of a parsimonious model for predicting excess deaths among those with COVID-19–a data-driven retrospective cohort study (2022)
50] Early Prediction of Neoplasms Using Machine Learning: A Study of Electronic Health Records from the Ministry of National Guard Health Affairs in Saudi Arabia (2022)
49] Late effects of cancer in children, teenagers and young adults: Population-based study on the burden of 183 conditions, in-patient and critical care admissions and years of life lost (2022)
48] Cumulative burden of psychiatric disorders and self-harm across 26 adult cancers (2022)
47] COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records (2022)
46] Authors Respond: Weight change and the onset of cardiovascular diseases: emulating trials using electronic health records (2021)
45] Application of ensemble clustering and survival tree analysis for identifying prognostic clinicogenomic features in patients with colorectal cancer from the 100,000 Genomes Project (2021)
44] ‘What is the risk to me from COVID-19?’: Public involvement in providing mortality risk information for people with ‘high-risk’ conditions for COVID-19 (OurRisk.CoV) (2021)
43] Antithrombotic therapy in patients with liver disease: population-based insights on variations in prescribing trends, adherence, persistence and impact on stroke and bleeding (2021)
42] Predicting the risk of cancer in adults using supervised machine learning: a scoping review (2021)
41] An Informatics Consult approach for generating clinical evidence for treatment decisions (2021)
40] Identifying adults at high-risk for change in weight and BMI in England: a longitudinal, large-scale, population-based cohort study using electronic health records (2021)
39] Linked electronic health records for research on a nationwide cohort of more than 54 million people in England: data resource (2021)
38] Excess deaths in people with cardiovascular diseases during the COVID-19 pandemic (2021)
37] Weight Change and the Onset of Cardiovascular Diseases: Emulating Trials Using Electronic Health Records (2021)
36] Estimated impact of the COVID-19 pandemic on cancer services and excess 1-year mortality in people with cancer and multimorbidity: near real-time data on cancer care, cancer deaths and a population-based cohort study (2020)
35] How to estimate the association between change in a risk factor and a health outcome? (2020)
34] Obesity during the COVID-19 pandemic: Both cause of high risk and potential effect of lockdown? A population-based electronic health record study (2020)
33] Could personalised risk prediction for type 2 diabetes using polygenic risk scores direct prevention, enhance diagnostics, or improve treatment? (2020)
32] Clinical academic research in the time of Corona: A simulation study in England and a call for action (2020)
31] Estimating the effect of reduced attendance at emergency departments for suspected cardiac conditions on cardiac mortality during the COVID-19 pandemic (2020)
30] An integrative pan-cancer investigation reveals common genetic and transcriptional alterations of AMPK pathway genes as important predictors of clinical outcomes across major cancer types (2020)
29] The hypoxic tumour microenvironment: A safe haven for immunosuppressive cells and a therapeutic barrier to overcome (2020)
28] Aberrations in Notch-Hedgehog signalling reveal cancer stem cells harbouring conserved oncogenic properties associated with hypoxia and immunoevasion (2019)
27] An immunoevasive strategy through clinically-relevant pan- cancer genomic and transcriptomic alterations of JAK-STAT signaling components (2019)
26] Timing gone awry: distinct tumour suppressive and oncogenic roles of the circadian clock and crosstalk with hypoxia signalling in diverse malignancies (2019)
25] The pan-cancer mutational landscape of the PPAR pathway reveals universal patterns of dysregulated metabolism and interactions with tumor immunity and hypoxia (2019)
24] Pan-cancer genomic amplifications underlie a Wnt hyperactivation phenotype associated with stem cell-like features leading to poor prognosis (2019)
23] Transcriptional landscape of DNA repair genes underpins a pan- cancer prognostic signature associated with cell cycle dysregulation and tumor hypoxia (2019)
22] Dual prognostic role for 2-oxoglutarate oxygenases in ten diverse cancer types: Implications for cell cycle regulation and cell adhesion maintenance (2018)
21] A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis (2019)
20] A novel signature derived from immunoregulatory and hypoxia genes predicts prognosis in liver and five other cancers (2019)
19] The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication (2019)
17] Mixed evolutionary origins of endogenous biomass- depolymerizing enzymes in animals (2018)
16] Epigenetic analyses of planarian stem cells demonstrate conservation of bivalent histone modifications in animal stem cells (2018)
15] Conservation of epigenetic regulation by the MLL3/4 tumour suppressor in planarian pluripotent stem cells (2018)
14] Glucose and glutamine availability regulate HepG2 transcriptional responses to low oxygen (2018)
13] Daytime variation in hepatitis C virus replication kinetics post liver transplant (2018)
12] Genome-wide analyses of the bHLH superfamily in crustaceans: reappraisal of higher order groupings and evidence for lineage-specific duplications (2018)
11] A TALE of shrimps: genome-wide survey of homeobox genes in 120 species from diverse crustacean taxa (2018)
10] Comparative genomic analysis of crustacean hyperglycemic hormone neuropeptide genes across diverse crustacean species (2018)
9] EvoRegen in animals: Time to uncover deep conservation or convergence of adult stem cell evolution and regenerative processes (2018)
8] The abrogation of condensin function provides independent evidence for defining the self-renewing population of pluripotent stem cells (2018)
6] Comparative genomic analysis of innate immunity reveals novel and conserved components in crustacean food crop species (2017)
5] The protein subunit of telomerase displays patterns of dynamic evolution and conservation across different metazoan taxa (2017)
4] The genome of the crustacean Parhyale hawaiensis, a model for animal development, regeneration, immunity and lignocellulose digestion (2016)
2] CIRCADIAN CLOCK-ASSOCIATED 1 regulates ROS homeostasis and oxidative stress responses (2012)
1] Positional information resolves structural variations and uncovers an evolutionarily divergent genetic locus in accessions of Arabidopsis thaliana (2011)